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Adenomatous Polyp

MedGen UID:
61657
•Concept ID:
C0206677
•
Neoplastic Process
Synonyms: Adenomatous Polyps; Polyp, Adenomatous; Polyps, Adenomatous
SNOMED CT: Adenomatous polyp (82375006); Polypoid adenoma (82375006)

Definition

A polypoid neoplasm arising from the glandular epithelium of the gastrointestinal tract. There is proliferation of glandular cells which may display dysplastic cytologic features. Representative examples include the adenomatous polyps of the colon and rectum. [from NCI]

Professional guidelines

PubMed

The Differential Diagnosis of Colorectal Polyps Using Colon Capsule Endoscopy.
Nakazawa K, Nouda S, Kakimoto K, Kinoshita N, Tanaka Y, Tawa H, Koshiba R, Naka Y, Hirata Y, Ota K, Kawakami K, Takeuchi T, Inoue T, Miyazaki T, Sanomura M, Nakamura S, Saito Y, Higuchi K
Intern Med 2021 Jun 15;60(12):1805-1812. Epub 2021 Jan 15 doi: 10.2169/internalmedicine.6446-20. PMID: 33456043Free PMC Article
Current status and future perspectives of endoscopic diagnosis and treatment of diminutive colorectal polyps.
Matsuda T, Kawano H, Hisabe T, Ikematsu H, Kobayashi N, Mizuno K, Oka S, Takeuchi Y, Tamai N, Uraoka T, Hewett D, Chiu HM
Dig Endosc 2014 Apr;26 Suppl 2:104-8. doi: 10.1111/den.12281. PMID: 24750158
Colorectal cancer update. Prevention, screening, treatment, and surveillance for high-risk groups.
Bond JH
Med Clin North Am 2000 Sep;84(5):1163-82, viii. doi: 10.1016/s0025-7125(05)70281-9. PMID: 11026923

Recent clinical studies

Etiology

Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Pharmacologically pertinent period of effect (PPPE).
Suissa M, LeLorier J
Pharmacoepidemiol Drug Saf 2020 Jan;29 Suppl 1(Suppl 1):61-67. Epub 2019 Jan 9 doi: 10.1002/pds.4714. PMID: 30628139Free PMC Article
Infectious causes of colorectal cancer.
Hasan N, Pollack A, Cho I
Infect Dis Clin North Am 2010 Dec;24(4):1019-39, x. doi: 10.1016/j.idc.2010.07.009. PMID: 20937463
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Diagnosis

Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
The pathology of bowel cancer screening.
Loughrey MB, Shepherd NA
Histopathology 2015 Jan;66(1):66-77. doi: 10.1111/his.12530. PMID: 25123305
The history of endometriosis.
Benagiano G, Brosens I, Lippi D
Gynecol Obstet Invest 2014;78(1):1-9. Epub 2014 May 16 doi: 10.1159/000358919. PMID: 24853333
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Therapy

Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora.
Zhou L, Zheng L, Xu B, Ye Z, Li D, Wang W
Orphanet J Rare Dis 2024 Feb 25;19(1):88. doi: 10.1186/s13023-024-03064-6. PMID: 38403687Free PMC Article
Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas.
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T, Oppezzi M, Gandini S, Bonanni B, DeCensi A
Nutrients 2023 Sep 7;15(18) doi: 10.3390/nu15183894. PMID: 37764678Free PMC Article
Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Yogurt consumption and colorectal polyps.
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Chemo- and dietary prevention of colorectal cancer.
Schatzkin A, Kelloff G
Eur J Cancer 1995 Jul-Aug;31A(7-8):1198-204. doi: 10.1016/0959-8049(95)00138-9. PMID: 7577021

Prognosis

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
The miRNA landscape of colorectal polyps.
Slattery ML, Herrick JS, Wolff RK, Mullany LE, Stevens JR, Samowitz W
Genes Chromosomes Cancer 2017 May;56(5):347-353. Epub 2017 Feb 1 doi: 10.1002/gcc.22436. PMID: 27925331Free PMC Article
Management of Diminutive Colon Polyps Based on Endoluminal Imaging.
Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J
Clin Gastroenterol Hepatol 2015 Nov;13(11):1860-6; quiz e168-9. Epub 2015 Jul 17 doi: 10.1016/j.cgh.2015.07.011. PMID: 26192139
Colorectal tumourigenesis.
Peiser J, Smith A, Bapat B, Stern H
Surg Oncol 1994 Aug;3(4):195-201. doi: 10.1016/0960-7404(94)90034-5. PMID: 7834110
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas.
Macis D, Briata IM, D'Ecclesiis O, Johansson H, Aristarco V, Buttiron Webber T, Oppezzi M, Gandini S, Bonanni B, DeCensi A
Nutrients 2023 Sep 7;15(18) doi: 10.3390/nu15183894. PMID: 37764678Free PMC Article
Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Pharmacologically pertinent period of effect (PPPE).
Suissa M, LeLorier J
Pharmacoepidemiol Drug Saf 2020 Jan;29 Suppl 1(Suppl 1):61-67. Epub 2019 Jan 9 doi: 10.1002/pds.4714. PMID: 30628139Free PMC Article
The miRNA landscape of colorectal polyps.
Slattery ML, Herrick JS, Wolff RK, Mullany LE, Stevens JR, Samowitz W
Genes Chromosomes Cancer 2017 May;56(5):347-353. Epub 2017 Feb 1 doi: 10.1002/gcc.22436. PMID: 27925331Free PMC Article
Management of Diminutive Colon Polyps Based on Endoluminal Imaging.
Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J
Clin Gastroenterol Hepatol 2015 Nov;13(11):1860-6; quiz e168-9. Epub 2015 Jul 17 doi: 10.1016/j.cgh.2015.07.011. PMID: 26192139

Recent systematic reviews

The incremental yield of adenoma detection with I-Scan versus high-definition white light colonoscopy-a systematic review and meta-analysis of randomized studies.
Hussain MR, Ali FS, Tangri A, Rashtak S, Joseph-Talreja M, Mutha PR, Wadhwa V, Guha S, DaVee RT, Thosani N
Int J Colorectal Dis 2023 Sep 27;38(1):240. doi: 10.1007/s00384-023-04533-3. PMID: 37755588
Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas.
Yao Y, Suo T, Andersson R, Cao Y, Wang C, Lu J, Chui E
Cochrane Database Syst Rev 2017 Jan 8;1(1):CD003430. doi: 10.1002/14651858.CD003430.pub2. PMID: 28064440Free PMC Article
ASGE Technology Committee systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting real-time endoscopic assessment of the histology of diminutive colorectal polyps.
ASGE Technology Committee, Abu Dayyeh BK, Thosani N, Konda V, Wallace MB, Rex DK, Chauhan SS, Hwang JH, Komanduri S, Manfredi M, Maple JT, Murad FM, Siddiqui UD, Banerjee S
Gastrointest Endosc 2015 Mar;81(3):502.e1-502.e16. Epub 2015 Jan 16 doi: 10.1016/j.gie.2014.12.022. PMID: 25597420

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